Homer 1b Regulates the Trafficking of Group I Metabotropic Glutamate Receptors*

@article{Roche1999Homer1R,
  title={Homer 1b Regulates the Trafficking of Group I Metabotropic Glutamate Receptors*},
  author={K. Roche and J. C. Tu and R. Petralia and B. Xiao and R. Wenthold and P. Worley},
  journal={The Journal of Biological Chemistry},
  year={1999},
  volume={274},
  pages={25953 - 25957}
}
The molecular basis for glutamate receptor trafficking to the plasma membrane is not understood. In the present study, we demonstrate that Homer 1b (H1b), a constitutively expressed splice form of the immediate early gene product Homer (now termed Homer 1a) regulates the trafficking and surface expression of group I metabotropic glutamate receptors. H1b inhibits surface expression of the metabotropic glutamate receptor mGluR5 in heterologous cells, causing mGluR5 to be retained in the… Expand
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