Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors.

@article{Kammermeier2007Homer1U,
  title={Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors.},
  author={Paul J. Kammermeier and Paul F Worley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 14},
  pages={6055-60}
}
Metabotropic glutamate receptors (mGluRs) and Homer proteins play critical roles in neuronal functions including plasticity, nociception, epilepsy, and drug addiction. Furthermore, Homer proteins regulate mGluR1/5 function by acting as adapters and facilitating coupling to effectors such as the inositol triphosphate receptor. However, although Homer proteins and their interaction with mGluRs have been the subject of intense study, direct measurements of Homer-induced changes in postsynaptic… CONTINUE READING
60 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 60 extracted citations

Similar Papers

Loading similar papers…