Homer: a protein that selectively binds metabotropic glutamate receptors

@article{Brakeman1997HomerAP,
  title={Homer: a protein that selectively binds metabotropic glutamate receptors},
  author={Paul R. Brakeman and Anthony A. Lanahan and Richard O'Brien and Karen Bandeen Roche and Carol A. Barnes and Richard L. Huganir and Paul F Worley},
  journal={Nature},
  year={1997},
  volume={386},
  pages={284-288}
}
Spatial localization and clustering of membrane proteins is critical to neuronal development and synaptic plasticity. Recent studies have identified a family of proteins, the PDZ proteins, that contain modular PDZ domains and interact with synaptic ionotropic glutamate receptors1 and ion channels2. PDZ proteins are thought to have a role in defining the cellular distribution of the proteins that interact with them. Here we report a novel dendritic protein, Homer, that contains a single, PDZ… CONTINUE READING
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