Homer: a protein that selectively binds metabotropic glutamate receptors

@article{Brakeman1997HomerAP,
  title={Homer: a protein that selectively binds metabotropic glutamate receptors},
  author={Paul R. Brakeman and Anthony A. Lanahan and Richard J. O’Brien and Katherine W Roche and Carol A. Barnes and R. L. Huganir and Paul F. Worley},
  journal={Nature},
  year={1997},
  volume={386},
  pages={284-288}
}
Spatial localization and clustering of membrane proteins is critical to neuronal development and synaptic plasticity. Recent studies have identified a family of proteins, the PDZ proteins, that contain modular PDZ domains and interact with synaptic ionotropic glutamate receptors1 and ion channels2. PDZ proteins are thought to have a role in defining the cellular distribution of the proteins that interact with them. Here we report a novel dendritic protein, Homer, that contains a single, PDZ… 
Homer as Both a Scaffold and Transduction Molecule
TLDR
Roles in glutamate receptor function and intracellular signaling in neurons are summarized, with recent data indicating that Homer proteins not only control expression and localization of mGlu receptors and channels, but also participate in signaling of glutamate receptors in neurons.
Emerging roles of Dlg-like PDZ proteins in the organization of the NMDA-type glutamatergic synapse.
TLDR
This review focuses on the best characterized PDZ-containing proteins that interact with N-methyl-D-aspartate (NMDA)-type glutamate receptors and discusses their functions in synaptic organization.
Modulation of synaptic signalling complexes by Homer proteins
  • U. Thomas
  • Biology
    Journal of neurochemistry
  • 2002
TLDR
This review will address primarily more recent studies on the regulation of Homer’1a expression and on the role of Homer/Vesl proteins in spine morphogenesis and receptor targeting and signalling.
The Homer-1 protein Ania-3 interacts with the plasma membrane calcium pump.
Effects of Vesl/Homer Proteins on Intracellular Signaling
TLDR
Members of the Vesl/Homer protein family have now been identified in other excitable cells in various muscle types and in a large number of nonexcitable cells.
Activity dependent dissociation of the Homer1 interactome
TLDR
It is concluded that Homer1 dissociates from mGlu5 and Shank3 following depolarization, but the data suggest that direct Homer1 interactions in the cortex may be more limited than expected.
Homer 1b Regulates the Trafficking of Group I Metabotropic Glutamate Receptors*
TLDR
It is demonstrated that Homer 1b (H1b), a constitutively expressed splice form of the immediate early gene product Homer (now termed Homer 1a) regulates the trafficking and surface expression of group I metabotropic glutamate receptors.
The Homer family proteins
SummaryThe Homer family of adaptor proteins consists of three members in mammals, and homologs are also known in other animals but not elsewhere. They are predominantly localized at the postsynaptic
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 28 REFERENCES
GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors
TLDR
GRIP is a new member of the PDZ domain-containing protein family which has seven PDZ domains and no catalytic domain and appears to serve as an adapter protein that links AMPA receptors to other proteins and may be critical for the clustering of AMPA receptor at excitatory synapses in the brain.
rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein.
TLDR
An inducible novel member of the Ras family of small GTP-binding proteins, termed Rheb, which is rapidly and transiently induced in hippocampal granule cells by seizures and by NMDA-dependent synaptic activity in the long term potentiation paradigm.
Narp, a novel member of the pentraxin family, promotes neurite outgrowth and is dynamically regulated by neuronal activity
TLDR
Because Narp is rapidly regulated by neuronal activity, its lectin and growth-promoting activities are likely to play role in the modification of cellular properties that underlie long-term plasticity.
Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases
TLDR
Functional and biochemical evidence is presented that cell-surface clustering of Shaker-subfamily K+ channels is mediated by the PSD-95 family of membrane-associated putative guanylate kinases, and the ability of PDZ domains to function as independent modules for protein–protein interaction, and their presence in other junction-associated molecules suggest that PDZ-domain-containing polypeptides may be widely involved in the organization of proteins at sites of membrane specialization.
Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95.
TLDR
The yeast two-hybrid system was used to show that the cytoplasmic tails of NMDA receptor subunits interact with a prominent postsynaptic density protein PSD-95, which may affect the plasticity of excitatory synapses.
Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals
TLDR
It is demonstrated that Rheb interacts with and appears to regulate Raf-1 kinase, an essential component of the H-Ras signaling pathway, which is potentiated by growth factors in combination with agents that increase cyclic AMP levels.
Numerous candidate plasticity-related genes revealed by differential cDNA cloning
TLDR
A highly sensitive differential complementary DNA cloning procedure is used to identify genes that may participate in long-term plasticity, suggesting that strong neuronal activation leads to de novo synthesis of vesicular and other synaptic components.
...
1
2
3
...