Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene

@article{Lufkin1992HomeoticTO,
  title={Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene},
  author={Thomas Lufkin and Manuel Mark and C. P. Hart and Pascal Doll{\'e} and M Lemeur and Pierre Chambon},
  journal={Nature},
  year={1992},
  volume={359},
  pages={835-841}
}
MURINEHox genes have been postulated to play a role in patterning of the embryonic body plan1–3. Gene disruption studies have suggested that for a given Hox complex, patterning of cell identity along the antero–posterior axis is directed by the more 'posterior' (having a more posterior rostral boundary of expression) Hox proteins expressed in a given cell4–6. This supports the 'posterior prevalence' model2, which also predicts that ectopic expression of a given Hox gene would result in altered… CONTINUE READING
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