Homeotic genes of the bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less

@article{Vachon1992HomeoticGO,
  title={Homeotic genes of the bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less
},
  author={Gilles Vachon and B Cohen and Christine Pfeifle and M.Elaine McGuffin and Juan Botas and Stephen Michael Cohen},
  journal={Cell},
  year={1992},
  volume={71},
  pages={437-450}
}
Homeotic genes encode transcription factors that are thought to specify segmental identity by regulating expression of subordinate genes. Limb development is repressed in the abdominal segments of the Drosophila embryo by the hometic genes of the Bithorax complex (BX-C). Localized expression of the homeobox gene Distal-less (DII) is required for leg development in thoracic segments. We have identified a minimal cis-regulatory enhancer element that directs DII expression in the larval leg… Expand
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