Homeostatic signals do not drive post-thymic T cell maturation.

  title={Homeostatic signals do not drive post-thymic T cell maturation.},
  author={Evan G. Houston and Tamar E. Boursalian and Pamela J Fink},
  journal={Cellular immunology},
  volume={274 1-2},
Recent thymic emigrants, the youngest T cells in the lymphoid periphery, undergo a 3 week-long period of functional and phenotypic maturation before being incorporated into the pool of mature, naïve T cells. Previous studies indicate that this maturation requires T cell exit from the thymus and access to secondary lymphoid organs, but is MHC-independent. We now show that post-thymic T cell maturation is independent of homeostatic and costimulatory pathways, requiring neither signals delivered… CONTINUE READING

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