Homeostatic role of transforming growth factor-beta in the oral cavity and esophagus of mice and its expression by mast cells in these tissues.

Abstract

Transforming growth factor-beta (TGF-beta) is a pleiotropic growth factor; its overexpression has been implicated in many diseases, making it a desirable target for therapeutic neutralization. In initial safety studies, mice were chronically treated (three times per week) with high doses (50 mg/kg) of a murine, pan-neutralizing, anti-TGF-beta antibody. Nine… (More)
DOI: 10.2353/ajpath.2009.080723

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Cite this paper

@article{Vitsky2009HomeostaticRO, title={Homeostatic role of transforming growth factor-beta in the oral cavity and esophagus of mice and its expression by mast cells in these tissues.}, author={Allison Vitsky and James S Waire and Robert Pawliuk and Arden Bond and Douglas Matthews and Emily Lacasse and Michael L Hawes and Carol A. Nelson and Susan M. Richards and Peter A. Piepenhagen and Richard D Garman and Laura Andrews and Beth L. Thurberg and Scott M. Lonning and Steve Ledbetter and Melanie C. Ruzek}, journal={The American journal of pathology}, year={2009}, volume={174 6}, pages={2137-49} }