Homeostatic regulation of intrinsic excitability and synaptic transmission in a developing visual circuit.

@article{Pratt2007HomeostaticRO,
  title={Homeostatic regulation of intrinsic excitability and synaptic transmission in a developing visual circuit.},
  author={Kara G Pratt and Carlos D Aizenman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 31},
  pages={8268-77}
}
One of the major challenges faced by the developing visual system is how to stably process visual information, yet at the same time remain flexible enough to accommodate growth and plasticity induced by visual experience. We find that in the Xenopus retinotectal circuit, during a period in development when the retinotectal map undergoes activity-dependent refinement and visual inputs strengthen, tectal neurons adapt their intrinsic excitability such that a stable relationship between the total… CONTINUE READING

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