Homeostatic regulation of bronchomotor tone by sympathetic activation during bronchoconstriction in normal and asthmatic humans.

@article{Sands1985HomeostaticRO,
  title={Homeostatic regulation of bronchomotor tone by sympathetic activation during bronchoconstriction in normal and asthmatic humans.},
  author={Mark F. Sands and Frank L. Douglas and Jayne Green and Arthur S. Banner and Gary L. Robertson and Alan R. Leff},
  journal={The American review of respiratory disease},
  year={1985},
  volume={132 5},
  pages={993-8}
}
It has been assumed previously that the sympathetic nervous system (SNS) serves to antagonize bronchoconstrictor stimuli. To assess the homeostatic regulatory effect elicited by exogenously induced bronchoconstriction, we studied the effect of inhaled methacholine on the SNS response in 12 normal and 9 asthmatic humans. Exogenous SNS response was assessed as change in plasma epinephrine and norepinephrine concentrations from basal levels during inhalation challenge. A 74 +/- 3% decrease in… CONTINUE READING