Homeostatic regulation of AMPA receptor expression at single hippocampal synapses.

  title={Homeostatic regulation of AMPA receptor expression at single hippocampal synapses.},
  author={Qingming Hou and Dawei Zhang and Larissa A. Jarzylo and Richard L. Huganir and Hengye Man},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={105 2},
Homeostatic synaptic response is an important measure in confining neuronal activity within a narrow physiological range. Whether or not homeostatic plasticity demonstrates synapse specificity, a key feature characteristic of Hebbian-type plasticity, is largely unknown. Here, we report that in cultured hippocampal neurons, alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid subtype glutamate receptor (AMPAR) accumulation is increased selectively in chronically inhibited single synapses… CONTINUE READING

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