Homeostatic proliferation plus regulatory T-cell depletion promotes potent rejection of B16 melanoma.

@article{Kline2008HomeostaticPP,
  title={Homeostatic proliferation plus regulatory T-cell depletion promotes potent rejection of B16 melanoma.},
  author={Justin P. Kline and Ian E. Brown and Yuan-yuan Zha and Christian Blank and John G. Strickler and Harald Wouters and Long Zhang and Thomas F Gajewski},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2008},
  volume={14 10},
  pages={3156-67}
}
PURPOSE To investigate the antitumor efficacy of T-cell anergy reversal through homeostatic proliferation and regulatory T-cell (Treg) depletion in a clinically relevant murine adoptive immunotherapy model. EXPERIMENTAL DESIGN B16 melanoma cells were engineered to express the model SIYRYYGL (SIY) antigen to enable immune monitoring. Tumor-specific T cells expanded in tumor-challenged wild-type hosts but became hyporesponsive. To examine whether lymphopenia-induced homeostatic proliferation… CONTINUE READING