Homeostatic proliferation in the mice with germline FoxP3 mutation and its contribution to fatal autoimmunity.

@article{Chang2008HomeostaticPI,
  title={Homeostatic proliferation in the mice with germline FoxP3 mutation and its contribution to fatal autoimmunity.},
  author={Xing Chang and Pan Zheng and Yang Liu},
  journal={Journal of immunology},
  year={2008},
  volume={181 4},
  pages={2399-406}
}
FoxP3 has emerged as a critical regulator for the development and function of regulatory T cells. Recent studies by several groups have demonstrated that FoxP3 is expressed outside T cell lineages. In this context, we have reported that germline mutation of FoxP3 caused defective thymopoiesis, although its potential contribution to autoimmune diseases has not been analyzed. In this study, we report that, during perinatal period, germline mutation of FoxP3 in scurfy mice caused lymphopenia in… CONTINUE READING
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