Homeostatic muffling

  title={Homeostatic muffling},
  author={ROGER C. Thomas and J. A. Coles and JOCHEN W. Deitmer},
High effective cytosolic H+ buffering in mouse cortical astrocytes attributable to fast bicarbonate transport
Within the time frame of determining physiological H+ buffering in cells, fast transport and equilibration of CO2/H+/HCO3− can make a major contribution to the total “effective” H+ buffer strength. Expand
Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle
The results show that astrocytes maintain local brain extracellular pH homeostasis via a neuronal activity-dependent release of bicarbonate, providing evidence of another important metabolic housekeeping function of these glial cells. Expand
Cellular Dynamics of Transition Metal Exchange on Proteins: A Challenge but a Bonanza for Coordination Chemistry
The issue of metal exchange in biology is reviewed with particular reference to iron and illustrating examples in patho-physiology, regulation, nutrition, and toxicity. Expand
Total and ionized serum magnesium and calcium levels during magnesium sulfate administration for preterm labor
There were no significant differences in serum Mg and Ca levels during MgSO4 administration for preterm labor compared to the before and after administration of Mgso4, and only I-Ca levels were not substantially changed. Expand
Zinc as a Gatekeeper of Immune Function
Molecular mechanisms underlying the development of a pro-inflammatory phenotype during zinc deficiency are reported, and links between altered zinc homeostasis and disease development are described, ensuring the benefits of zinc supplementation for a malfunctioning immune system become clear. Expand
The Kinetic Response of the Proteome in A549 Cells Exposed to ZnSO4 Stress
This study further elucidates the understanding of dynamic nature of the cellular response to zinc stress and the mechanism of zinc homeostasis and identified 50 differentially expressed proteins which are predominantly involved in metabolic process, cellular process or developmental process, and function as binding, catalytic activity or structural molecule activity. Expand
Zinc Signals in Cellular Functions and Disorders
Zinc plays an indispensable role in life. It regulates a great number of protein functions including transcription factors, enzymes, adapters, receptors, and growth factors as a structural orExpand
Selective metal ion-capturing by striped nanoparticles
Nanomaterials have attracted lots of attention due to their tremendous potential in extensive fields, ranging from biology, physics, and chemistry to electronics, and also already proven theirExpand
Zinc biochemistry: from a single zinc enzyme to a key element of life.
  • W. Maret
  • Medicine, Biology
  • Advances in nutrition
  • 2013
It is fair to conclude that the impact of zinc for health and disease will be at least as far-reaching as that of iron. Expand