Homeostatic increase in excitability in area CA1 after Schaffer collateral transection in vivo.

@article{Dinocourt2011HomeostaticII,
  title={Homeostatic increase in excitability in area CA1 after Schaffer collateral transection in vivo.},
  author={C{\'e}line Dinocourt and Stephanie L Aungst and Kun Yang and Scott M. Thompson},
  journal={Epilepsia},
  year={2011},
  volume={52 9},
  pages={1656-65}
}
PURPOSE Epilepsy is a significant long-term consequence of traumatic brain injury (TBI) and is likely to result from multiple mechanisms. One feature that is common to many forms of TBI is denervation. We asked whether chronic partial denervation in vivo would lead to a homeostatic increase in the excitability of a denervated cell population. METHODS To answer this question, we took advantage of the unique anatomy of the hippocampus where the input to the CA1 neurons, the Schaffer collaterals… CONTINUE READING
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