Homeostatic chemokine receptors and organ-specific metastasis

@article{Zlotnik2011HomeostaticCR,
  title={Homeostatic chemokine receptors and organ-specific metastasis},
  author={A. Zlotnik and A. Burkhardt and B. Homey},
  journal={Nature Reviews Immunology},
  year={2011},
  volume={11},
  pages={597-606}
}
It has been 10 years since the role of a chemokine receptor, CXCR4, in breast cancer metastasis was first documented. Since then, the field of chemokines and cancer has grown significantly, so it is timely to review the progress, analyse the studies to date and identify future challenges facing this field. Metastasis is the major factor that limits survival in most patients with cancer. Therefore, understanding the molecular mechanisms that control the metastatic behaviour of tumour cells is… Expand

Paper Mentions

Interventional Clinical Trial
In mouse models and in patients, expression of the chemokine receptor CXCR4 on various cancers has been correlated with aggressive biological behavior, including increased rates… Expand
ConditionsCancer
InterventionDrug
Chemokines and Chemokine Receptors: Orchestrating Tumor Metastasization
Chemokine Regulation of Cell Trafficking in Lung Cancer Metastasis
The Role of CCL21/CCR7 Chemokine Axis in Breast Cancer Progression
Targeting Chemokines and Chemokine Receptors in Melanoma and Other Cancers
CCL2/CCR2 signaling in cancer pathogenesis
Role of Chemokines in Thyroid Cancer Microenvironment: Is CXCL8 the Main Player?
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 136 REFERENCES
CXCR4 and cancer
The importance of the CXCL12-CXCR4 chemokine ligand-receptor interaction in prostate cancer metastasis.
Potential of CXCR4 antagonists for the treatment of metastatic lung cancer
Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.
Chemokines in tumor-associated angiogenesis
...
1
2
3
4
5
...