Homeostatic chemokine receptors and organ-specific metastasis

@article{Zlotnik2011HomeostaticCR,
  title={Homeostatic chemokine receptors and organ-specific metastasis},
  author={Albert Zlotnik and Amanda M. Burkhardt and Bernhard Homey},
  journal={Nature Reviews Immunology},
  year={2011},
  volume={11},
  pages={597-606}
}
It has been 10 years since the role of a chemokine receptor, CXCR4, in breast cancer metastasis was first documented. Since then, the field of chemokines and cancer has grown significantly, so it is timely to review the progress, analyse the studies to date and identify future challenges facing this field. Metastasis is the major factor that limits survival in most patients with cancer. Therefore, understanding the molecular mechanisms that control the metastatic behaviour of tumour cells is… 
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References

SHOWING 1-10 OF 142 REFERENCES
Inhibition of Breast Cancer Metastasis by Selective Synthetic Polypeptide against CXCR4
TLDR
The role of a synthetic antagonist 14-mer peptide (TN14003) in inhibiting metastasis of breast cancer by inhibiting migration is investigated and may prove useful as a diagnostic tool to identify CXCR4 receptor-positive tumor cells in culture and tumors in paraffin-embedded clinical samples.
CXCR4 and cancer
TLDR
Interestingly, cancer stem cells also express CXCR4, indicating that the CX CR4‐SDF‐1 axis may direct the trafficking and metastasis of these cells to organs that express high levels of SDF‐ 1, such as the lymph nodes, lungs, liver, and bone.
The importance of the CXCL12-CXCR4 chemokine ligand-receptor interaction in prostate cancer metastasis.
TLDR
It is demonstrated that human prostate cell lines derived from metastases express functional CXCR4 receptor and that CXCL12 ligand enhances their migratory capabilities.
Potential of CXCR4 antagonists for the treatment of metastatic lung cancer
TLDR
Data is summarized about the cellular and molecular microenvironment in small-cell lung cancer and non-small- cell lung cancer, as well as the role of CXCR4 in tumor–stroma crosstalk, and the current status of the preclinical and clinical development of CxCR4 antagonists.
Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.
Involvement of chemokine receptors in breast cancer metastasis
TLDR
It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
Chemokines and chemokine receptors in neurological disease: Raise, retain, or reduce?
Multiple functions of CXCL12 in a syngeneic model of breast cancer
TLDR
Therapies that boost CXCL12 levels at the primary tumor site may prove more effective in the treatment of metastatic breast cancer, and the need to consider carefully therapeutic strategies that block CxCL12 signaling is highlighted.
Chemokines in tumor-associated angiogenesis
TLDR
The pharmacologic control of tumor angiogenesis presents a promising strategy for novel anticancer therapeutics and is highlighted in the context of chemokines and their receptors.
CXCR4 mediates the proliferation of glioblastoma progenitor cells.
...
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