Homeostatic bioenergetic network regulation - a novel concept to avoid pharmacoresistance in epilepsy.

@article{Boison2011HomeostaticBN,
  title={Homeostatic bioenergetic network regulation - a novel concept to avoid pharmacoresistance in epilepsy.},
  author={Detlev Boison and Susan A. Masino and Jonathan Geiger},
  journal={Expert opinion on drug discovery},
  year={2011},
  volume={6 7},
  pages={713-724}
}
INTRODUCTION: Despite epilepsy being one of the most prevalent neurological disorders, one third of all patients with epilepsy cannot adequately be treated with available antiepileptic drugs. One of the significant causes for the failure of conventional pharmacotherapeutic treatment is the development of pharmacoresistance in many forms of epilepsy. The problem of pharmacoresistance has called for the development of new conceptual strategies that improve future drug development efforts. AREAS… CONTINUE READING