Homeostatic Regulation of Salmonella-Induced Mucosal Inflammation and Injury by IL-23

Abstract

IL-12 and IL-23 regulate innate and adaptive immunity to microbial pathogens through influencing the expression of IFN-γ, IL-17, and IL-22. Herein we define the roles of IL-12 and IL-23 in regulating host resistance and intestinal inflammation during acute Salmonella infection. We find that IL-23 alone is dispensable for protection against systemic spread… (More)
DOI: 10.1371/journal.pone.0037311

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@inproceedings{Awoniyi2012HomeostaticRO, title={Homeostatic Regulation of Salmonella-Induced Mucosal Inflammation and Injury by IL-23}, author={Muyiwa Awoniyi and Samuel I. Miller and Christopher B. Wilson and Adeline M Hajjar and Kelly D. Smith}, booktitle={PloS one}, year={2012} }