Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice

@article{Komatsu2007HomeostaticLO,
  title={Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice},
  author={M. Asaliaru Komatsu and Satoshi Waguri and Masato Koike and Yu-shin Sou and Takashi Ueno and Taichi Hara and Noboru Mizushima and Jun-ichi Iwata and Junji Ezaki and Shigeo Murata and Jun Hamazaki and Yasumasa Nishito and Shun-ichiro Iemura and Tohru Natsume and Toru Yanagawa and Junya Uwayama and Eiji Warabi and Hiroshi Yoshida and Tetsuro Ishii and Akira Kobayashi and Masayuki Yamamoto and Zhenyu Yue and Yasuo Uchiyama and Eiki Kominami and Keiji Tanaka},
  journal={Cell},
  year={2007},
  volume={131},
  pages={1149-1163}
}
Inactivation of constitutive autophagy results in formation of cytoplasmic protein inclusions and leads to liver injury and neurodegeneration, but the details of abnormalities related to impaired autophagy are largely unknown. Here we used mouse genetic analyses to define the roles of autophagy in the aforementioned events. We report that the ubiquitin- and LC3-binding protein "p62" regulates the formation of protein aggregates and is removed by autophagy. Thus, genetic ablation of p62… CONTINUE READING
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