Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis

  title={Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis},
  author={Richard W Clayton and Klaus G{\"o}bel and Carien M. Niessen and Ralf Paus and Maurice A. M. van Steensel and Xinhong Lim},
  journal={British Journal of Dermatology},
Sebaceous glands (SGs) are appendages of mammalian skin that produce a mixture of lipids known as sebum. Acne vulgaris is an exceptionally common skin condition, characterized by elevated sebum production, altered sebum composition, and the formation of infundibular cysts, called comedones. Comedo‐associated SGs are atrophic, suggesting that comedo formation involves abnormal differentiation of progenitor cells that generate the SG and infundibulum: the ‘comedo switch’. Understanding the… 

Acne vulgaris: role of the immune system

New findings have explained the relationship that occurs inside the acne lesion and the immune system has a key role since it is stimulated by the other participants involved, such as phylotypes of Propionibacterium acnes, antimicrobial peptides, sebaceous glands, matrix metalloproteinases, and other immune system pathways.

Stem and progenitor cells in sebaceous gland development, homeostasis and pathologies

Recent progress in unravelling cellular mechanisms underlying SG development, homeostasis and sebaceous tumor formation is discussed and the role of stem and progenitor cells in controlling SG physiology and disease processes is assessed.

Pathogenesis of acne vulgaris

The aim of this article is to highlight the update on the sebaceous gland involvement, the immunity role and the cutaneous microbiome in acne vulgaris pathogenesis.

Sex hormones and acne: State of the art

Insight is provided into the involvement of sex hormones, particularly androgens, in skin homeostasis and acne pathogenesis, including comedogenesis, lipogenesis, microbiota, and inflammation.

Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations

This review presents several aspects of the innovative concept of sebaceous immunobiology, which summarizes the numerous activities of the sebaceous gland including its classical physiological and

Recent advances in understanding and managing acne

Multidisciplinary investigations into the pathogenesis of acne from the perspectives of sebaceous gland biology, sebum, genetics, keratinization, differentiation, hair cycles, immunology, bacteriology, and wound healing have elucidated its pathogenesis.

MicroRNA Cross-Involvement in Acne Vulgaris and Hidradenitis Suppurativa: A Literature Review

This review provides a starting point for further studies aimed at investigating the role of miRNAs in AV and HS for their possible use as diagnostic-therapeutic targets.

Sebocyte differentiation as a new target for acne therapy: an in vivo experience

Acne, a disease of the sebaceous gland with multifactorial pathogenesis, affects more than 85% of adolescents. A better deepening of the mechanisms underlying the disease is needed to define

Honokiol Improves Acne-like Lesions in a Rabbit Ear Model by Alleviating Hyperkeratosis and Sebum Secretion

Topical 2.5% honokiol cream obviously improved the comedones and hyperkeratosis and effectively reduced sebum secretion, as shown by Oil Red O staining, and the effects were equivalent to those of adapalene gel without local side effects.

Anti-acne effects of Castanea crenata bur extract and identification of active compound

The findings suggest that CBE have potential to be a multi-target agent for acne vulgaris and a good source of ellagic acid as an anti-sebum compound.



The effects of isotretinoin on follicular and sebaceous gland differentiation

Findings provide no support for the proposition that alteration in the process of follicular keratinization forms a substantial part of the mode of action of isotretinoin.

A practical guide for the study of human and murine sebaceous glands in situ

This methods review concludes by suggesting quantitative (immuno‐)histomorphometric methods for standardised SG evaluation, which are particularly instructive when addressing specific SG research questions in the two most commonly investigated species in SG research, humans and mice.

Acne vulgaris: proliferative cells in sebaceous glands

  • G. Plewig
  • Medicine, Biology
    The British journal of dermatology
  • 1974
The proliferative activity of sebaceous glands of uninvolved skin from acne patients was analysed by means of 3H‐thymidine autoradiography and by planimetry for the differentiating cell pool with germinative cells and large lipid cells.

Development and homeostasis of the sebaceous gland.

Role of sebaceous glands in inflammatory dermatoses.

Genetically modified laboratory mice with sebaceous glands abnormalities

This survey will become a helpful information source for researchers with a primary interest in SG but also for researchers from unrelated fields that are unexpectedly confronted with a SG phenotype in newly generated mouse lines.

Changes in the sebaceous gland in patients with male pattern hair loss (androgenic alopecia)

The sebaceous gland and the follicular bulge region have important role in biology of the hair and the distribution of the bulge stem cells in pathological conditions of male pattern hair loss or androgenic alopecia (AGA).

Endocrinologic control of the development and activity of the human sebaceous gland.

It is clear from the foregoing considerations that the development and secretory activity of the sebaceous gland of man is influenced by hormonal factors, androgenic steroids are the hormones principally responsible for these effects.

New cell formation in human sebaceous glands.

Intradermal injection of thymidine-H3 by biopsy removal 40 minutes to 36 days later revealed a characteristic pattern of human sebaceous gland activity, and steady state replenishment from the periphery for at least 2 to 4 weeks.

Acne, the Skin Microbiome, and Antibiotic Treatment

Understanding the skin microbiome associated with acne and the effects of antibiotic use on the skin commensals is highly relevant and critical to clinicians.