Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis

@article{Clayton2019HomeostasisOT,
  title={Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis},
  author={Richard W Clayton and Klaus G{\"o}bel and Carien M. Niessen and Ralf Paus and Maurice A. M. van Steensel and Xinhong Lim},
  journal={British Journal of Dermatology},
  year={2019},
  volume={181}
}
Sebaceous glands (SGs) are appendages of mammalian skin that produce a mixture of lipids known as sebum. Acne vulgaris is an exceptionally common skin condition, characterized by elevated sebum production, altered sebum composition, and the formation of infundibular cysts, called comedones. Comedo‐associated SGs are atrophic, suggesting that comedo formation involves abnormal differentiation of progenitor cells that generate the SG and infundibulum: the ‘comedo switch’. Understanding the… 

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