Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity.

@article{Bonora2000HomeostasisMA,
  title={Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity.},
  author={Enzo Bonora and Giovanni Targher and Mar{\'i}a P Alberiche and Riccarcdo C Bonadonna and Francesca Saggiani and Marina Zenere and T Monauni and Michele Muggeo},
  journal={Diabetes care},
  year={2000},
  volume={23 1},
  pages={57-63}
}
OBJECTIVE To evaluate whether the homeostasis model assessment (HOMA) is a reliable surrogate measure of in vivo insulin sensitivity in humans. RESEARCH DESIGN AND METHODS In the present study, we compared insulin sensitivity as assessed by a 4-h euglycemic (approximately 5 mmol/l) hyperinsulinemic (approximately 300 pmol/l) clamp with HOMA in 115 subjects with various degrees of glucose tolerance and insulin sensitivity. RESULTS We found a strong correlation between clamp-measured total… CONTINUE READING
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