Homeostasis and the Importance for a Balance Between AKT/mTOR Activity and Intracellular Signaling

Abstract

The AKT family of serine threonine kinases is of critical importance with regard to growth factor signaling, cell proliferation, survival and oncogenesis. Engagement of signaling receptors induces the lipid kinase, phosphatidylinositol 3-kinase (PI3K), which enables the activation of AKT. Responsive to the PI3K/AKT pathway is the mammalian target of… (More)

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Cite this paper

@inproceedings{Altomare2012HomeostasisAT, title={Homeostasis and the Importance for a Balance Between AKT/mTOR Activity and Intracellular Signaling}, author={D Altomare and AR Khaled}, booktitle={Current medicinal chemistry}, year={2012} }