Homeodomain transcription factor and tumor suppressor Prep1 is required to maintain genomic stability.

@article{Iotti2011HomeodomainTF,
  title={Homeodomain transcription factor and tumor suppressor Prep1 is required to maintain genomic stability.},
  author={Giorgio Iotti and Elena Longobardi and Silvia Masella and Leila Dardaei and Francesca de Santis and Nicola Micali and Francesco Blasi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 29},
  pages={E314-22}
}
Prep1 is a homeodomain transcription factor that is essential in embryonic development and functions in the adult as a tumor suppressor. We show here that Prep1 is involved in maintaining genomic stability and preventing neoplastic transformation. Hypomorphic homozygous Prep1(i/i) fetal liver cells and mouse embryonic fibroblasts (MEFs) exhibit increased basal DNA damage and normal DNA damage response after γ-irradiation compared with WT. Cytogenetic analysis shows the presence of numerous… CONTINUE READING

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Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis.

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The absence of Prep1 causes p53-dependent apoptosis of mouse pluripotent epiblast cells

LC Fernandez-Diaz
Development • 2010
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