Homeodomain protein CDX2 regulates COX-2 expression in colorectal cancer.

  title={Homeodomain protein CDX2 regulates COX-2 expression in colorectal cancer.},
  author={Sang-Pyo Kim and Jong-Wook Park and Sung-Hee Lee and Jun Hee Lim and Byeong-Churl Jang and Sang-Han Lee and In-hwan Jang and J D Freund and Seong-il Suh and Kyo Cheol Mun and Dae-kyu Song and Eun-Mi Ha and Won-Jae Lee and Taeg Kyu Kwon},
  journal={Biochemical and biophysical research communications},
  volume={315 1},
CDX2 is an intestine-specific tumor suppressor gene encoding homeodomain-containing transcription factor, which is involved in a variety of developmental, proliferating, and differentiating processes. Moreover, the expression of CDX2 is reduced in a subset of primary colorectal cancers. In contrast, cyclooxygenase-2 (COX-2) is often up-regulated in human colorectal cancers. However, the molecular relationship between CDX2 down-regulation and COX-2 up-regulation is unknown. Here we show that… CONTINUE READING
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