Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies

Abstract

The HIPK2 (serine/threonine homeodomain-interacting protein kinase 2) is a "caretaker" gene, its inactivation increases tumorigenicity while its activation inhibits tumor growth. This report reviews the anti-tumorigenic mechanisms of HIPK2, which include promotion of apoptosis, inhibition of angiogenesis in hypoxia, prevention of tumor invasion/metastasis… (More)
DOI: 10.18632/oncotarget.14723

Topics

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