Homeobox protein Hex induces SMemb/nonmuscle myosin heavy chain-B gene expression through the cAMP-responsive element.

@article{Sekiguchi2001HomeoboxPH,
  title={Homeobox protein Hex induces SMemb/nonmuscle myosin heavy chain-B gene expression through the cAMP-responsive element.},
  author={Kenichi Sekiguchi and Masahiko Kurabayashi and Yuko Oyama and Yasushi Aihara and Toru Tanaka and Hiroshi Sakamoto and Yuichi Hoshino and Tosaku Kanda and Tomoyuki Yokoyama and Yasuyo Shimomura and Hideki Iijima and Yoshio Ohyama and Ryozo Nagai},
  journal={Circulation research},
  year={2001},
  volume={88 1},
  pages={52-8}
}
Recent studies have shown that the homeobox gene Hex plays an important role in inducing differentiation of vascular endothelial cells. In this study, we examined the expression of Hex in vascular smooth muscle cells (VSMCs) in vitro and in vivo. Immunohistochemistry showed a marked induction of Hex protein in neointimal VSMCs after balloon injury in rat aorta. Western and reverse transcriptase-polymerase chain reaction analyses demonstrated that Hex was abundantly expressed in cultured VSMCs… CONTINUE READING

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Transcriptional activation of the zinc finger transcription factor BTEB2 gene by Egr-1 through mitogen-activated protein kinase pathways in vascular smooth muscle cells

K Kowase, M Kurabayashi, Y Hoshino, Y Ohyama, R. Nagai
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