Homeobox Genes in Embryogenesis and Pathogenesis

  title={Homeobox Genes in Embryogenesis and Pathogenesis},
  author={Manuel Mark and Filippo M Rijli and Pierre Chambon},
  journal={Pediatric Research},
The homeobox, a 60-amino acid-encoding DNA sequence, originally discovered in the genome of the fruit fly Drosophila, was subsequently identified throughout the three kingdoms of multicellular organisms. Homeobox-containing genes encode DNA-binding proteins that regulate gene expression and control various aspects of morphogenesis and cell differentiation. In particular, the Hox family of clustered homeobox genes plays a fundamental role in the morphogenesis of the vertebrate embryo, providing… CONTINUE READING
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