Homeobox B3 Promotes Capillary Morphogenesis and Angiogenesis

  title={Homeobox B3 Promotes Capillary Morphogenesis and Angiogenesis},
  author={Connie Myers and Aubri L Charboneau and Nancy J. Boudreau},
  journal={The Journal of Cell Biology},
  pages={343 - 352}
Endothelial cells (EC) express several members of the Homeobox (Hox) gene family, suggesting a role for these morphoregulatory mediators during angiogenesis. We have previously established that Hox D3 is required for expression of integrin alphavbeta3 and urokinase plasminogen activator (uPA), which contribute to EC adhesion, invasion, and migration during angiogenesis. We now report that the paralogous gene, Hox B3, influences angiogenic behavior in a manner that is distinct from Hox D3… CONTINUE READING
60 Citations
38 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 60 extracted citations


Publications referenced by this paper.
Showing 1-10 of 38 references

Hox D3 induces an angiogenic phenotype in endothelial cells

  • N. Boudreau, C. Andrews, A. Srebrow, A. Ravanpay, D. A. Cheresh.
  • J. Cell Biol. 139:257–264.
  • 1997
Highly Influential
17 Excerpts

dothelial cells express a novel , tumor necrosis factor – alpha - regulated variant of HOXA 9

  • G. Savageau, U. Thorsteindottir, +4 authors R. K. Humphries
  • J . Biol . Chem .
  • 1999

Similar Papers

Loading similar papers…