Hom s 4, an IgE-Reactive Autoantigen Belonging to a New Subfamily of Calcium-Binding Proteins, Can Induce Th Cell Type 1-Mediated Autoreactivity1

@article{Aichberger2005HomS4,
  title={Hom s 4, an IgE-Reactive Autoantigen Belonging to a New Subfamily of Calcium-Binding Proteins, Can Induce Th Cell Type 1-Mediated Autoreactivity1},
  author={Karl J. Aichberger and Irene Mittermann and Renate Reininger and Susanne Seiberler and Ines Swoboda and Susanne Spitzauer and Tamara Kopp and Georg Stingl and Wolfgang R. Sperr and Peter Valent and Andreas Repa and Barbara Bohle and Dietrich Kraft and Rudolf Valenta},
  journal={The Journal of Immunology},
  year={2005},
  volume={175},
  pages={1286 - 1294}
}
Skin inflammation in atopic dermatitis starts with Th2 and IgE-mediated responses against exogenous allergens and, for unknown reasons, resembles features of a Th1-driven reaction in the chronic stages. We report the characterization of a human protein, Hom s 4, recognized by IgE autoantibodies from atopic dermatitis patients. The complete Hom s 4 cDNA codes for a 54-kDa basic protein containing two typical calcium-binding domains separated by an unusually long α-helical domain. Therefore, Hom… 

Figures and Tables from this paper

The IgE-reactive autoantigen Hom s 2 induces damage of respiratory epithelial cells and keratinocytes via induction of IFN-gamma.
TLDR
The data demonstrate that the Hom s 2 autoantigen can cause IFN-gamma-mediated cell damage and could be inhibited with a neutralizing anti-IFN-Gamma antibody.
Calcium-binding proteins and their role in allergic diseases.
Immunoglobulin E‐binding autoantigens: biochemical characterization and clinical relevance
  • R. Crameri
  • Biology, Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2012
TLDR
It is reasonable to assume that IgE‐mediated cross‐linking of FcRIε receptors on effector cells can elicit the same symptoms as those induced by environmental allergens, and this could explain exacerbations of chronic allergic diseases in the absence of external exposure.
Serum IgE autoantibodies target keratinocytes in patients with atopic dermatitis.
TLDR
It is concluded that IgE autoreactivity is common, particularly among severe AD patients, and that non-transformed primary cells are needed for characterization of the entire spectrum of IgE-defined autoantigens.
Immunoglobulin-E-Mediated Reactivity to Self Antigens: A Controversial Issue
TLDR
Increasing evidence shows that self allergens could play a decisive role in the exacerbation of long-lasting atopic diseases, and the only observation supporting a clinical role of IgE-mediated autoreactivity is confined to the fact that IgE levels against self antigens correlate with disease severity.
Pathogenic mechanisms of IgE-mediated inflammation in self-destructive autoimmune responses
TLDR
Novel evidence is presented supporting that triggering of IgE receptors in pDC induces LC3-associated phagocytosis, a cellular process also known as LAP that is associated with interferon responses and defines IgE’s role in autoimmune humoral responses.
Humoral and Cellular Autoreactivity to Epidermal Proteins in Atopic Dermatitis
TLDR
The pathogenesis of AD is evaluated and the emerging role of autoreactivity to various keratinocyte antigens involving both the humoral and cellular components of the immune system is evaluated.
Role of IgE in autoimmunity.
Most Highly Cytokinergic IgEs Have Polyreactivity to Autoantigens
TLDR
It is shown that most HC, but not PC, IgEs exhibit polyreactivity to autoantigens, supporting the autoimmune mechanism in the pathogenesis of atopic dermatitis.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 53 REFERENCES
Molecular characterization of an autoallergen, Hom s 1, identified by serum IgE from atopic dermatitis patients.
TLDR
To unravel the molecular nature of IgE-defined autoantigens, serum IgE from atopic dermatitis patients were used to screen a human epithelial cDNA expression library and an almost complete sequence identity with a recently described antigen recognized by cytotoxic T cells of a squamous cell carcinoma patient was exhibited.
Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients
  • S. Natter, S. Seiberler, R. Valenta
  • Biology, Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1998
TLDR
It is shown that IgE autoreactivity is found predominantly in AD patients with severe skin manifestations and revealed the molecular nature of four IgE autoantigens, which may contribute to exacerbation and/or perpetuation of severe atopic diseases even in the absence of exogenous allergens.
Immunoglobulin E response to human proteins in atopic patients.
TLDR
The results suggest that IgE autoimmunity occurs frequently in atopic dermatitis patients and may be of pathogenic relevance for the chronicity of skin manifestations typical of this disease.
Characterization of IgE–Reactive Autoantigens in Atopic Dermatitis 1. Subcellular Distribution and Tissue–Specific Expression
TLDR
Serum IgE from AD patients is used to investigate the distribution of autoantigens in subcellular fractions of the human epithelial cell line A431 and in human tissue specimens and showed that IgE–reactive autoantIGens can be detected in the nuclear > microsomal > mitochondrial > cytoplasmic fraction of A431 cells.
Characterization of IgE–Reactive Autoantigens in Atopic Dermatitis
TLDR
The results indicate that IgE autoreactivity may represent a true form of autoimmunity directed against partly denatured peptide epitopes which may be boosted by exogenous allergen contact.
Calcium‐dependent immunoglobulin E recognition of the apo‐ and calcium‐bound form of a cross‐reactive two EF‐hand timothy grass pollen allergen, Phl p 7
TLDR
Recombinant Phl p 7 may be used for diagnosis and perhaps treatment of a group of patients who suffer from allergy to pollens of many unrelated plant species and represents an example for the conformation‐dependent IgE recognition of an allergen.
Autoallergy: a pathogenetic factor in atopic dermatitis?
TLDR
It is suggested that at least two pathomechanisms could play a role in autoallergy, and IgE-mediated presentation of autoallergens may activate autoreactive T cells to release proinflammatory cytokines, contributing to the magnitude of the allergic tissue reaction.
Recombinant Carp Parvalbumin, the Major Cross-Reactive Fish Allergen: A Tool for Diagnosis and Therapy of Fish Allergy1
TLDR
RCyp c 1.01 reacted with IgE from all fish-allergic patients tested, induced specific and dose-dependent basophil histamine release, and contained most of the IgE epitopes present in natural allergen extracts from cod, tuna, and salmon, suggesting it may be used to identify patients suffering from IgE-mediated fish allergy.
Nonallergic individuals recognize the same T cell epitopes of Bet v 1, the major birch pollen allergen, as atopic patients.
TLDR
It can be concluded, that nonatopic and allergic individuals display the same repertoire of T cell specificities, and the activation of allergen-specific TCC leads to a higher ratio of produced IL-4 vs IFN-gamma, which is responsible for enhanced IgE production.
Allergen specificity of skin-infiltrating T cells is not restricted to a type-2 cytokine pattern in chronic skin lesions of atopic dermatitis.
TLDR
The studies demonstrate that allergen specificity of skin-infiltrating T cells is not restricted to a type-2 cytokine pattern in lesional atopic dermatitis, and supports the concept that interferon-gamma expression has major pathogenetic relevance for the chronic phase of atopy dermatitis.
...
1
2
3
4
5
...