Holoprosencephaly and related midline cerebral anomalies: a review.

  title={Holoprosencephaly and related midline cerebral anomalies: a review.},
  author={Richard W. Leech and Robert M Shuman},
  journal={Journal of child neurology},
  volume={1 1},
We propose a simple pathogenetic mechanism that reduces a bewildering variety of central nervous system malformations to a manageable group sharing defects of midline prosencephalic growth. It is neither new nor innovative, but attempts to summarize many pathologic entities within a concept that accounts for known embryologic events and the sequence and timing of those events. We propose midline prosencephalic dysgenesis as a category of malformations including aprosencephaly, holoprosencephaly… CONTINUE READING
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