Hologram quantitative structure activity relationship studies on 5-HT6 antagonists.

@article{Doddareddy2004HologramQS,
  title={Hologram quantitative structure activity relationship studies on 5-HT6 antagonists.},
  author={Munikumar Reddy Doddareddy and Yeon Joo Lee and Yong Seo Cho and Kyung Il Choi and Hun Yeong Koh and Ae Nim Pae},
  journal={Bioorganic & medicinal chemistry},
  year={2004},
  volume={12 14},
  pages={3815-24}
}
Predictive hologram quantitative structure activity relationship (HQSAR) models were developed for a series of arylsulfonamide compounds acting as specific 5-HT6 antagonists. A training set containing 48 compounds served to establish the model. The best HQSAR model was generated using atoms, bond, and connectivity as fragment distinction and 4-7 as fragment… CONTINUE READING