Holocentromeres are dispersed point centromeres localized at transcription factor hotspots

  title={Holocentromeres are dispersed point centromeres localized at transcription factor hotspots},
  author={Florian A Steiner and Steven Henikoff},
Centromeres vary greatly in size and sequence composition, ranging from 'point' centromeres with a single cenH3-containing nucleosome to 'regional' centromeres embedded in tandemly repeated sequences to holocentromeres that extend along the length of entire chromosomes. Point centromeres are defined by sequence, whereas regional and holocentromeres are epigenetically defined by the location of cenH3-containing nucleosomes. In this study, we show that Caenorhabditis elegans holocentromeres are… CONTINUE READING
Highly Cited
This paper has 1,423 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 28 extracted citations

1,424 Citations

Citations per Year
Semantic Scholar estimates that this publication has 1,424 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 71 references

Partitioning the C

  • SG Gu, A. Fire
  • elegans genome by nucleosome modification…
  • 2010
Highly Influential
6 Excerpts

The role of the kinetochore in the chromosomal evolution of the heteroptera and homoptera

  • F. Schrader
  • Evolution 1:134–142. doi: 10.2307/2405489.
  • 1947
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…