Holocentromeres are dispersed point centromeres localized at transcription factor hotspots

@inproceedings{Steiner2014HolocentromeresAD,
  title={Holocentromeres are dispersed point centromeres localized at transcription factor hotspots},
  author={Florian A Steiner and Steven Henikoff},
  booktitle={eLife},
  year={2014}
}
Centromeres vary greatly in size and sequence composition, ranging from 'point' centromeres with a single cenH3-containing nucleosome to 'regional' centromeres embedded in tandemly repeated sequences to holocentromeres that extend along the length of entire chromosomes. Point centromeres are defined by sequence, whereas regional and holocentromeres are epigenetically defined by the location of cenH3-containing nucleosomes. In this study, we show that Caenorhabditis elegans holocentromeres are… CONTINUE READING
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