Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation

@article{Yehuda2016HolocaustEI,
  title={Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation},
  author={Rachel Yehuda and Nikolaos P. Daskalakis and Linda M. Bierer and Heather N. Bader and Torsten Klengel and Florian Holsboer and Elisabeth B. Binder},
  journal={Biological Psychiatry},
  year={2016},
  volume={80},
  pages={372-380}
}
Identification of dynamic glucocorticoid-induced methylation changes at the FKBP5 locus
TLDR
This study highlights that DNAm levels within regulatory regions of the FKBP5 locus show dynamic changes following a GC challenge and suggest that factors influencing the dynamics of this regulation may contribute to the previously reported alterations in DNAm associated with current and past ELS exposure.
DNA methylation at stress-related genes is associated with exposure to early life institutionalization.
TLDR
A lasting impact of early severe social deprivation on methylation patterns in two stress-related genes, FKBP5 and SLC6A4, is suggested, linking early adversity and epigenetic variation in children.
No association between FKBP5 gene methylation and acute and long-term cortisol output
TLDR
The findings did not reveal strong evidence for a robust effect of CT on FK BP5 intron 7 DNAM status, and FKBP5 DNAM levels were found to be unrelated to acute cortisol stress reactivity and long-term cortisol concentration in hair.
The effects of childhood maltreatment on epigenetic regulation of stress-response associated genes: an intergenerational approach
TLDR
The hypothesis of a long-lasting impact of CM on the biological epigenetic regulation of stress-response mediators is supported and it is suggested for the first time that these specific epigenetic patterns might not be directly transmitted to the next generation.
Intergenerational Transmission of DNA Methylation Signatures Associated with Early Life Stress
TLDR
The field of epigenetic transmission is just beginning to enter the epigenomic era by using genome-wide analyses, and approaches remain of strong interest to human studies, first in order to help to assess the relevance of the previous targeted studies, and second to discover new important epigenetic modifications of potential clinical importance.
Non-genetic transgenerational transmission of bipolar disorder: targeting DNA methyltransferases
TLDR
Bipolar disorder has been shown to present a strong1 and complex2 genetic component, even though common variants found in genome-wide association studies still account for only a small fraction of BD heritability, and non-genetic mechanisms have a role in its risk and onset.
Epigenetics and the Exposome
TLDR
Common techniques that are applied for untargeted approaches; and to measure regional modifications and gene-specific aberrations to measure epigenetic marks on a genomic scale are described.
Inter- and transgenerational inheritance of behavioral phenotypes
Epigenetic derepression of FKBP5 by aging and stress contributes to NF-ĸB-driven inflammation and cardiovascular risk
TLDR
It is found that aging and stress synergize to epigenetically derepress FKBP5, a protein implicated in stress physiology, which provides molecular insights into stress-related disease and may point to novel biomarker and treatment possibilities.
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TLDR
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