Hollow fibers of poly(lactide-co-glycolide) and poly(ε-caprolactone) blends for vascular tissue engineering applications.

@article{Diban2013HollowFO,
  title={Hollow fibers of poly(lactide-co-glycolide) and poly(ε-caprolactone) blends for vascular tissue engineering applications.},
  author={Nazely Diban and Suvi P. Haimi and Lydia A.M. Bolhuis-Versteeg and Sandra Soares Teixeira and Susanna Miettinen and Andr{\'e} A. Poot and Dirk W Grijpma and Dimitrios Stamatialis},
  journal={Acta biomaterialia},
  year={2013},
  volume={9 5},
  pages={
          6450-8
        }
}
At present the manufacture of small-diameter blood vessels is one of the main challenges in the field of vascular tissue engineering. Currently available vascular grafts rapidly fail due to development of intimal hyperplasia and thrombus formation. Poly(lactic-co-glycolic acid) (PLGA) hollow fiber (HF) membranes have previously been proposed for this application, but as we show in the present work, they have an inhibiting effect on cell proliferation and rather poor mechanical properties. To… CONTINUE READING
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