Holins kill without warning.

@article{Grndling2001HolinsKW,
  title={Holins kill without warning.},
  author={Angelika Gr{\"u}ndling and M D Patrick Manson and Ryland Young},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 16},
  pages={
          9348-52
        }
}
Holins comprise the most diverse functional group of proteins known. They are small bacteriophage-encoded proteins that accumulate during the period of late-protein synthesis after infection and cause lysis of the host cell at a precise genetically programmed time. It is unknown how holins achieve temporal precision, but a conserved feature of their function is that energy poisons subvert the normal scheduling mechanism and instantly trigger membrane disruption. On this basis, timing has been… CONTINUE READING
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