Holey barrier : claudins and the regulation of brain endothelial permeability

@inproceedings{Matter2003HoleyB,
  title={Holey barrier : claudins and the regulation of brain endothelial permeability},
  author={Karl Matter and Maria Susana Balda},
  year={2003}
}
ndothelial tight junctions (TJs)* are an important functional part of the blood-brain barrier (BBB). In this issue, Nitta et al. (2003) demonstrate that claudin-5, a transmembrane protein of TJs, is a critical determinant of BBB permeability in mice. Unexpectedly, knockout of claudin-5 did not result in a general breakdown of TJs but in a selective increase in paracellular permeability of small molecules. This suggests that the BBB can be manipulated to allow selective diffusion of small… CONTINUE READING

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