The holding power of metallic screws in cancellous bone and metallic plates in cortical bone was tested in sixty rabbits (n = 60). These metallic devices were fixed either without support or with the support of plastic material or autogenous bone graft. The fixation firmness was studied radiographically and by a test of the bonding strength. After six weeks, the mean value of the holding power of screws in cancellous bone without support was 440 N, and that of screws supported by polymethylmethacrylate 674 N and by bone graft 540 N. Corresponding values after twelve weeks were 436 N, 664 N, and 616 N. Fixation with polymethylmethacrylate was better than either fixation without support (P < 0.001, t-test) or fixation with bone graft (P < 0.01), whereas fixation with bone graft was better than fixation without support (P < 0.07). The best fixation was achieved by polymethylmethacrylate according to group mean values. Our investigation of the holding power of plates in cortical bone did not reveal any statistically significant differences between the methods used.