Hoiamide D, a marine cyanobacteria-derived inhibitor of p53/MDM2 interaction.

Abstract

Bioassay-guided fractionation of two cyanobacterial extracts from Papua New Guinea has yielded hoiamide D in both its carboxylic acid and conjugate base forms. Hoiamide D is a polyketide synthase (PKS)/non-ribosomal peptide synthetase (NRPS)-derived natural product that features two consecutive thiazolines and a thiazole, as well as a modified isoleucine… (More)
DOI: 10.1016/j.bmcl.2011.10.054

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