Hofbauer cells of M2a, M2b and M2c polarization may regulate feto-placental angiogenesis.

@article{Loegl2016HofbauerCO,
  title={Hofbauer cells of M2a, M2b and M2c polarization may regulate feto-placental angiogenesis.},
  author={Jelena Loegl and Ursula Hiden and Erika Nussbaumer and C Schliefsteiner and Silvija Cvitic and Ingrid Lang and C. Wadsack and Berthold Huppertz and Gernot Desoye},
  journal={Reproduction},
  year={2016},
  volume={152 5},
  pages={
          447-55
        }
}
The human placenta comprises a special type of tissue macrophages, the Hofbauer cells (HBC), which exhibit M2 macrophage phenotype. Several subtypes of M2-polarized macrophages (M2a, M2b and M2c) exist in almost all tissues. Macrophage polarization depends on the way of macrophage activation and leads to the expression of specific cell surface markers and the acquisition of specific functions, including tissue remodeling and the promotion of angiogenesis. The placenta is a highly vascularized… CONTINUE READING
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