Hoechst 33342 induced reactive oxygen species and impaired expression of cytochrome c oxidase subunit 1 leading to cell death in irradiated human cancer cells

@article{Athar2011Hoechst3I,
  title={Hoechst 33342 induced reactive oxygen species and impaired expression of cytochrome c oxidase subunit 1 leading to cell death in irradiated human cancer cells},
  author={Mohammad Athar and Nabo Kumar Chaudhury and Mohammad Ejaz Hussain and Rajeev K. Varshney},
  journal={Molecular and Cellular Biochemistry},
  year={2011},
  volume={352},
  pages={281-292}
}
Oxidative stress and mitochondrial dysfunction in cancer cells represent features that may be exploited therapeutically. We determined whether minor groove binding ligand Hoechst 33342, known to induce mitochondrial dysfunction via increase in reactive oxygen species (ROS), enhances killing of human head and neck cancer (KB) cells mediated by impaired expression of mitochondrial protein involved in electron transfer. Elevation in ROS generation, increase in ΔΨm, down regulation of cytochrome c… CONTINUE READING
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