Hodgkin lymphoma is today divided in two distinct groups: classical Hodgkin lymphoma, and nodular lymphocytepredominant Hodgkin lymphoma . The classical type includes 4 subtypes: (1) nodular sclerosis, (2) mixed cellularity, (3) lymphocyte rich, and (4) lymphocyte depleted. All these subtypes have mononuclear (Hodgkin) and multinucleated (Reed-Sternberg) cells with identical phenotype as well as genetic features. However, their clinical and cytologic features differ and they will therefore be described separately. It should be pointed though out that subtyping of classical Hodgkin lymphoma has little prognostic information compared with the clinical stage . Nodular lymphocyte-predominant Hodgkin lymphoma differs from classical Hodgkin lymphoma with respect to clinical behavior, cytomorphology and immunocytophenotype and will thus be discussed separately .