Hodgkin disease-derived cell lines expressing ubiquitous mitochondrial creatine kinase show growth inhibition by cyclocreatine treatment independent of apoptosis.

@article{Kornacker2001HodgkinDC,
  title={Hodgkin disease-derived cell lines expressing ubiquitous mitochondrial creatine kinase show growth inhibition by cyclocreatine treatment independent of apoptosis.},
  author={Martin Kornacker and Uwe Schlattner and Theo Wallimann and MichaelR. Verneris and Robert S. Negrin and Birgit Kornacker and Andrea Staratschek-Jox and Volker Diehl and J{\"u}rgen Wolf},
  journal={International journal of cancer},
  year={2001},
  volume={94 4},
  pages={
          513-9
        }
}
Ubiquitous mitochondrial creatine kinase (uMtCK), a key enzyme in energy metabolism, was identified by differential display PCR to be specifically overexpressed in L1236, the first cell line of definite Hodgkin origin. RT-PCR confirmed overexpression of uMtCK in the L1236 cell line and the absence of cytosolic B-CK, which is co-expressed with MtCK physiologically. Cyclocreatine (cCr), whose phosphorylated form is a very poor substrate for CK, inhibited proliferation of the L1236 cell line… CONTINUE READING

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