• Biology, Medicine
  • Published in Anticancer research 1988

Hodgkin and Reed-Sternberg cell associated monoclonal antibodies HRS-1 and HRS-2 react with activated cells of lymphoid and monocytoid origin.

@article{Pfreundschuh1988HodgkinAR,
  title={Hodgkin and Reed-Sternberg cell associated monoclonal antibodies HRS-1 and HRS-2 react with activated cells of lymphoid and monocytoid origin.},
  author={M G Pfreundschuh and E. Mommertz and Markus Meissner and Alfred Christian Feller and R Hassa and G R Krueger and Volker Diehl},
  journal={Anticancer research},
  year={1988},
  volume={8 2},
  pages={
          217-24
        }
}
The two monoclonal antibodies HRS-1 and HRS-2, which were obtained after immunization with the Hodgkin's derived cell line L428, detect different epitopes on a 120 kd antigen. This antigen is present on Hodgkin- and Reed-Sternberg (H&RS) cells in all subtypes of Hodgkin's lymphoma and on large cell anaplastic non-Hodgkin's lymphomas. The H&RS- associated 120 kd antigen appears to be a non-lineage specific activation antigen, as it is not present on normal B and T lymphocytes or monocytes, but… CONTINUE READING

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