Hodgkin’s lymphoma and its association with EBV and HIV infection

@article{Grewal2018HodgkinsLA,
  title={Hodgkin’s lymphoma and its association with EBV and HIV infection},
  author={Ravnit Grewal and Alexandra Iulia Irimie and Nasheen Naidoo and Nooroudien Mohamed and Bobe Petrushev and Manogari Chetty and Ciprian Ionut Tomuleasa and Emmanuel Akinola Abayomi},
  journal={Critical Reviews in Clinical Laboratory Sciences},
  year={2018},
  volume={55},
  pages={102 - 114}
}
Abstract Hodgkin's lymphoma (HL) constitutes a clonal expansion of what appears to be malignant B cells. Viruses are involved in its pathogenesis, such as the Epstein–Barr virus (EBV) and human immunodeficiency virus (HIV). Since these viral infections have been shown to play key roles in the pathogenesis of HL, countries with a prevalence of HIV and EBV represent interesting population targets to study the pathogenesis of HL, linking the evolution of the disease with viral infections. Usually… 

Virus-Mediated Inhibition of Apoptosis in the Context of EBV-Associated Diseases: Molecular Mechanisms and Therapeutic Perspectives

The molecular mechanism of anti-apoptotic actions of a set of EBV proteins, the pro-survival role of non-coding viral transcripts: EBV-encoded small RNAs (EBERs) and microRNAs (miRNAs) and the influence of EBv on the expression, activity and/or intracellular distribution of B-cell lymphoma 2 (Bcl-2) protein family members, has been presented.

Unraveling the Mystery of Gray Zone Lymphoma in Human Immunodeficiency Virus-Seropositive Patients: Two Cases

Two HIV patients diagnosed with GZL that were successfully treated at a single community-based institution are described and DA-EPOCH-R was able to induce durable remission with limited side effects and it represents a viable strategy for treating patients in this population.

Epstein barr virus associated Hodgkin and non-Hodgkin lymphoma

The result of the current study revealed that EBV-LMP-1 marker found in 12.5% of cases that had been diagnosed by PCR and IHC, which is higher than expected.

Castleman’s disease in the HIV-endemic setting

A significant increase in the incidence of HIV-associated multicentric CD over the last decade in the authors' area in South Africa is demonstrated.

Paraneoplastic hypereosinophilia in a patient with peripheral T cell lymphoma, not otherwise specified

This is a report associating this symptom to a peripheral T-cell lymphoma, not other specified, thus emphasizing the importance of a complex approach for the management of the oncological patient.

Studies on prerequisites for antigen-specific active immunotherapy

Specific intralesional DC subpopulations are present in NPC and the C-lectin receptor CD207, involved in antigen cross-presentation, is frequently expressed.

Effect of age and gender on EBV associated-Hodgkin lymphoma among sample of Iraqi patients

A cross sectional study on the age-specific prevalence of Epstein–Barr virus (EBV) infection in patients recruited from Middle Euphrates Cancer Research Unit Laboratory, from pre-existing samples to identify factors associated with its acquisition.

Hodgkin lymphoma in children and adolescents: Advances in pathology, diagnosis, and treatment strategies

This review report gives extensive account about the pathophysiology, clinical presentation, histopathological diagnosis, modern investigation techniques, the most recent risk adapted treatment strategies, and the use and effect of novel medications used for the treatment of children with Hodgkin lymphoma.

References

SHOWING 1-10 OF 115 REFERENCES

Epstein–Barr virus-associated lymphomas

Recent developments in the understanding of EBV-associated lymphomagenesis in both the immunocompetent and Immunocompromised host are reviewed.

Human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) related lymphomas, pathology view point.

The current knowledge regarding the pathogenesis of these malignancies, the interplay between HIV and EBV co-infection in the development of certain HIV related lymphomas, and the emerging paradigm that suggests that HIV may play a direct role in lymphomagenesis are explored are explored.

Human Immunodeficiency Virus Infection and Hodgkin's Lymphoma in South Africa: An Emerging Problem

The similarities and differences of a South African cohort of HIV-HL are presented, where more than half the patients are HAART naive at diagnosis of HL.

Spectrum of Epstein-Barr virus-associated diseases.

The current understanding of the role of EBV in the development of Burkitt lymphoma, Hodgkin lymphomas, nasopharyngeal carcinoma, and other EBV-associated diseases is discussed.

The biology of Hodgkin's lymphoma

The B-cell nature of the pathognomonic Hodgkin and Reed–Sternberg cells has been revealed, along with several recurrent genetic lesions, and the pathogenetic role for Epstein–Barr virus infection has been substantiated.

AIDS-related lymphomas in Nigeria.

The significance or otherwise of HIV/AIDS epidemics in the pathogenesis of lymphomas in a population of Nigerians with the disease is highlighted and no single case of AIDS-associated BL was seen, despite the fact that Burkitt's lymphoma is endemic in this part of the world.

HIV infection and lymphoma

Following the introduction of highly active antiretroviral therapy, the risk for developing lymphoma in the context of HIV infection has decreased and the clinical outcome has improved.

Characterization of Lymphomas in a High Prevalence HIV Setting

This study provides a baseline for monitoring the impact of HIV and management thereof on lymphoma trends, and highlights the need for strengthening of cancer registries within South Africa and the region.

The Haematologist and the Infective Complications of HIV Infection.

The haematologist may have a role in the diagnosis of AIDS-related lymphomas involving the bone marrow, particularly Burkitt's and Burkitt-like lymphoma and Hodgkin's disease.
...