Hodgkin's reed-sternberg cell line (KM-H2) promotes a bidirectional differentiation of CD4+CD25+Foxp3+ T cells and CD4+ cytotoxic T lymphocytes from CD4+ naive T cells.

@article{Tanijiri2007HodgkinsRC,
  title={Hodgkin's reed-sternberg cell line (KM-H2) promotes a bidirectional differentiation of CD4+CD25+Foxp3+ T cells and CD4+ cytotoxic T lymphocytes from CD4+ naive T cells.},
  author={Tsutomu Tanijiri and Toshiki Shimizu and Kazutaka Uehira and Takashi Yokoi and Hideki Amuro and Hiroyuki Sugimoto and Yoshitaro Torii and Kenichirou Tajima and Tomoki Ito and Ryuichi Amakawa and Shirou Fukuhara},
  journal={Journal of leukocyte biology},
  year={2007},
  volume={82 3},
  pages={576-84}
}
A recent report revealed that a large population of Hodgkin's lymphoma-infiltrating lymphocytes (HLILs) consisted of regulatory T cells. In this study, we cocultured CD4+ naive T cells with KM-H2, which was established as a Hodgkin's Reed-Sternberg cell line, to clarify their ability to induce CD25+ Forkhead box P3+ (Foxp3+) T cells. The characteristic analyses of T cells cocultured with KM-H2 revealed the presence of CD4+CD25+ T cells. They expressed CTLA-4, glucocorticoid-induced TNFR family… CONTINUE READING
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