Hodgkin's disease and peripheral T-cell lymphoma: composite lymphoma with evidence of Epstein-Barr virus infection.

@article{Niedobitek2000HodgkinsDA,
  title={Hodgkin's disease and peripheral T-cell lymphoma: composite lymphoma with evidence of Epstein-Barr virus infection.},
  author={Gerald U. Niedobitek and Irith Baumann and T. Brabletz and R. P. Lisner and Cornelia Winkelmann and G. W. van der Helm and Thomas W. Kirchner},
  journal={The Journal of pathology},
  year={2000},
  volume={191 4},
  pages={394-9}
}
This paper reports the case of a patient with a composite lymphoma consisting of nodular sclerosing Hodgkin's disease and peripheral T-cell lymphoma. The Hodgkin and Reed-Sternberg (HRS) cells harboured the Epstein-Barr virus (EBV) and displayed a type II EBV latency (LMP1(+)/EBNA2(-)), whereas the neoplastic T-cells were EBV-negative. Four years later, the patient presented with a relapse of the peripheral T-cell lymphoma. In situ hybridization revealed numerous EBV-carrying lymphocytes, which… CONTINUE READING

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