Hodgkin's disease: study of treatment intensities and incidences of second malignancies.

@article{Rodriguez1993HodgkinsDS,
  title={Hodgkin's disease: study of treatment intensities and incidences of second malignancies.},
  author={Maria Alma Rodriguez and Lillian M. Fuller and Susan O Zimmerman and Pamela K. Allen and Barry W. Brown and Mark F Munsell and Fredrick B. Hagemeister and Peter Mclaughlin and William S. Velasquez and Forrest Swan},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={1993},
  volume={4 2},
  pages={125-31}
}
BACKGROUND Advances in radiotherapy and chemotherapy have gradually increased cure rates for patients with Hodgkin's disease. With improved long-term survivals, increases in observed second malignancies over those of the general population have been reported as early as 1972. Recently, a number of investigators have suggested that the relative importance of recognized risk factors contributing to the development of acute myelogenous leukemia (AML), non-Hodgkin's lymphomas, and solid tumors may… CONTINUE READING

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Hodgkin 's disease : study of treatment intensities and incidences of second malignancies .
Advances in radiotherapy and chemotherapy have gradually increased cure rates for patients with Hodgkin 's disease .
Advances in radiotherapy and chemotherapy have gradually increased cure rates for patients with Hodgkin 's disease .
Recently , a number of investigators have suggested that the relative importance of recognized risk factors contributing to the development of acute myelogenous leukemia ( AML ) , non - Hodgkin 's lymphomas , and solid tumors may be different .
Recently , a number of investigators have suggested that the relative importance of recognized risk factors contributing to the development of acute myelogenous leukemia ( AML ) , non - Hodgkin 's lymphomas , and solid tumors may be different .
Recently , a number of investigators have suggested that the relative importance of recognized risk factors contributing to the development of acute myelogenous leukemia ( AML ) , non - Hodgkin 's lymphomas , and solid tumors may be different .
Recently , a number of investigators have suggested that the relative importance of recognized risk factors contributing to the development of acute myelogenous leukemia ( AML ) , non - Hodgkin 's lymphomas , and solid tumors may be different .
Recently , a number of investigators have suggested that the relative importance of recognized risk factors contributing to the development of acute myelogenous leukemia ( AML ) , non - Hodgkin 's lymphomas , and solid tumors may be different .
Sixty - six instances of second malignancy were documented as follows : AML 14 , non - Hodgkin 's lymphoma 14 , and solid tumors 38 .
Sixty - six instances of second malignancy were documented as follows : AML 14 , non - Hodgkin 's lymphoma 14 , and solid tumors 38 .
Recently , a number of investigators have suggested that the relative importance of recognized risk factors contributing to the development of acute myelogenous leukemia ( AML ) , non - Hodgkin 's lymphomas , and solid tumors may be different .
Kaplan - Meier methodology was used to calculate overall and determinate survivals and occurrences of acute myelogenous leukemia , non - Hodgkin 's lymphoma , and solid tumors .
The overall incidence of second malignancy was significantly greater than the expected incidence of 21.75 ( p = 0.0001 ) and it was also significant for AML , non - Hodgkin 's lymphoma and solid tumors .
The overall incidence of second malignancy was significantly greater than the expected incidence of 21.75 ( p = 0.0001 ) and it was also significant for AML , non - Hodgkin 's lymphoma and solid tumors .
Recently , a number of investigators have suggested that the relative importance of recognized risk factors contributing to the development of acute myelogenous leukemia ( AML ) , non - Hodgkin 's lymphomas , and solid tumors may be different .
Recently , a number of investigators have suggested that the relative importance of recognized risk factors contributing to the development of acute myelogenous leukemia ( AML ) , non - Hodgkin 's lymphomas , and solid tumors may be different .
Recently , a number of investigators have suggested that the relative importance of recognized risk factors contributing to the development of acute myelogenous leukemia ( AML ) , non - Hodgkin 's lymphomas , and solid tumors may be different .
Kaplan - Meier methodology was used to calculate overall and determinate survivals and occurrences of acute myelogenous leukemia , non - Hodgkin 's lymphoma , and solid tumors .
The overall incidence of second malignancy was significantly greater than the expected incidence of 21.75 ( p = 0.0001 ) and it was also significant for AML , non - Hodgkin 's lymphoma and solid tumors .
The overall incidence of second malignancy was significantly greater than the expected incidence of 21.75 ( p = 0.0001 ) and it was also significant for AML , non - Hodgkin 's lymphoma and solid tumors .
Recently , a number of investigators have suggested that the relative importance of recognized risk factors contributing to the development of acute myelogenous leukemia ( AML ) , non - Hodgkin 's lymphomas , and solid tumors may be different .
Kaplan - Meier methodology was used to calculate overall and determinate survivals and occurrences of acute myelogenous leukemia , non - Hodgkin 's lymphoma , and solid tumors .
The overall incidence of second malignancy was significantly greater than the expected incidence of 21.75 ( p = 0.0001 ) and it was also significant for AML , non - Hodgkin 's lymphoma and solid tumors .
The overall incidence of second malignancy was significantly greater than the expected incidence of 21.75 ( p = 0.0001 ) and it was also significant for AML , non - Hodgkin 's lymphoma and solid tumors .
Recently , a number of investigators have suggested that the relative importance of recognized risk factors contributing to the development of acute myelogenous leukemia ( AML ) , non - Hodgkin 's lymphomas , and solid tumors may be different .
Kaplan - Meier methodology was used to calculate overall and determinate survivals and occurrences of acute myelogenous leukemia , non - Hodgkin 's lymphoma , and solid tumors .
Sixty - six instances of second malignancy were documented as follows : AML 14 , non - Hodgkin 's lymphoma 14 , and solid tumors 38 .
Sixty - six instances of second malignancy were documented as follows : AML 14 , non - Hodgkin 's lymphoma 14 , and solid tumors 38 .
Sixty - six instances of second malignancy were documented as follows : AML 14 , non - Hodgkin 's lymphoma 14 , and solid tumors 38 .
Sixty - six instances of second malignancy were documented as follows : AML 14 , non - Hodgkin 's lymphoma 14 , and solid tumors 38 .
Recently , a number of investigators have suggested that the relative importance of recognized risk factors contributing to the development of acute myelogenous leukemia ( AML ) , non - Hodgkin 's lymphomas , and solid tumors may be different .
Kaplan - Meier methodology was used to calculate overall and determinate survivals and occurrences of acute myelogenous leukemia , non - Hodgkin 's lymphoma , and solid tumors .
Recently , a number of investigators have suggested that the relative importance of recognized risk factors contributing to the development of acute myelogenous leukemia ( AML ) , non - Hodgkin 's lymphomas , and solid tumors may be different .
Recently , a number of investigators have suggested that the relative importance of recognized risk factors contributing to the development of acute myelogenous leukemia ( AML ) , non - Hodgkin 's lymphomas , and solid tumors may be different .
The overall incidence of second malignancy was significantly greater than the expected incidence of 21.75 ( p = 0.0001 ) and it was also significant for AML , non - Hodgkin 's lymphoma and solid tumors .
The overall incidence of second malignancy was significantly greater than the expected incidence of 21.75 ( p = 0.0001 ) and it was also significant for AML , non - Hodgkin 's lymphoma and solid tumors .
The overall incidence of second malignancy was significantly greater than the expected incidence of 21.75 ( p = 0.0001 ) and it was also significant for AML , non - Hodgkin 's lymphoma and solid tumors .
The overall incidence of second malignancy was significantly greater than the expected incidence of 21.75 ( p = 0.0001 ) and it was also significant for AML , non - Hodgkin 's lymphoma and solid tumors .
Sixty - six instances of second malignancy were documented as follows : AML 14 , non - Hodgkin 's lymphoma 14 , and solid tumors 38 .
Sixty - six instances of second malignancy were documented as follows : AML 14 , non - Hodgkin 's lymphoma 14 , and solid tumors 38 .
Kaplan - Meier methodology was used to calculate overall and determinate survivals and occurrences of acute myelogenous leukemia , non - Hodgkin 's lymphoma , and solid tumors .
Kaplan - Meier methodology was used to calculate overall and determinate survivals and occurrences of acute myelogenous leukemia , non - Hodgkin 's lymphoma , and solid tumors .
Sixty - six instances of second malignancy were documented as follows : AML 14 , non - Hodgkin 's lymphoma 14 , and solid tumors 38 .
Sixty - six instances of second malignancy were documented as follows : AML 14 , non - Hodgkin 's lymphoma 14 , and solid tumors 38 .
Analyses for risk of second malignancy demonstrated that age > or = 40 years , stage III or stage IV disease , and treatment with chemotherapy only were all associated with a significantly higher risk of second malignancy than any of the other factors .
Analyses for risk of second malignancy demonstrated that age > or = 40 years , stage III or stage IV disease , and treatment with chemotherapy only were all associated with a significantly higher risk of second malignancy than any of the other factors .
Sixty - six instances of second malignancy were documented as follows : AML 14 , non - Hodgkin 's lymphoma 14 , and solid tumors 38 .
The overall incidence of second malignancy was significantly greater than the expected incidence of 21.75 ( p = 0.0001 ) and it was also significant for AML , non - Hodgkin 's lymphoma and solid tumors .
The fact that patients with stages III and IV disease had an increased risk of second malignancy regardless of age suggests that biologic factors related to the tumor also may have been significant .
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