HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

  title={HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer},
  author={Charles J. David and M. -S. Chen and Marcela C Assanah and Peter Canoll and James L Manley},
When oxygen is abundant, quiescent cells efficiently extract energy from glucose primarily by oxidative phosphorylation, whereas under the same conditions tumour cells consume glucose more avidly, converting it to lactate. This long-observed phenomenon is known as aerobic glycolysis, and is important for cell growth. Because aerobic glycolysis is only useful to growing cells, it is tightly regulated in a proliferation-linked manner. In mammals, this is partly achieved through control of… CONTINUE READING
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