Hlx homeo box gene is essential for an inductive tissue interaction that drives expansion of embryonic liver and gut.

@article{Hentsch1996HlxHB,
  title={Hlx homeo box gene is essential for an inductive tissue interaction that drives expansion of embryonic liver and gut.},
  author={B Hentsch and Ian S Lyons and Rong Li and Lynne Hartley and Thierry J Lints and Jerry M. Adams and Richard P. Harvey},
  journal={Genes & development},
  year={1996},
  volume={10 1},
  pages={70-9}
}
The divergent murine homeo box gene Hlx is expressed in restricted hematopoietic cell types and, during embryogenesis, prominently in visceral mesenchyme of the developing liver, gall bladder, and gut. Targeted disruption of the gene has now established that it plays a key role in visceral organogenesis. Embryos homozygous for the mutation died around embryonic day 15 with anemia and severe hypoplasia of the liver and gut. Liver ontogeny commenced normally with formation of the liver… CONTINUE READING