Hitting the right spot: Mechanism of action of OPB-31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3).

@article{Brambilla2015HittingTR,
  title={Hitting the right spot: Mechanism of action of OPB-31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3).},
  author={Lara Brambilla and Davide Genini and Erik Laurini and Jessica Merulla and Laurent Perez and Maurizio Fermeglia and Giuseppina M. Carbone and Sabrina Pricl and Carlo Vittorio Catapano},
  journal={Molecular oncology},
  year={2015},
  volume={9 6},
  pages={1194-206}
}
STAT3 is a key element in many oncogenic pathways and, like other transcription factors, is an attractive target for development of novel anticancer drugs. However, interfering with STAT3 functions has been a difficult task and very few small molecule inhibitors have made their way to the clinic. OPB-31121, an anticancer compound currently in clinical trials, has been reported to affect STAT3 signaling, although its mechanism of action has not been unequivocally demonstrated. In this study, we… CONTINUE READING
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