Hit identification and biological evaluation of anticancer pyrazolopyrimidines endowed with anti-inflammatory activity.

Abstract

In recent years, several studies have proposed the cyclo-oxygenases (COXs) as therapeutic targets in the prevention of cancer. Some epidemiological investigations highlighted that nonsteroidal anti-inflammatory drugs (NSAIDs) reduced the development of several malignant diseases, including colorectal cancer. 3,4] NSAIDs inhibit COXs and consequently… (More)
DOI: 10.1002/cmdc.201000165

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